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KMID : 0359319840240010024
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Korean Journal of Veterinary Research
1984 Volume.24 No. 1 p.24 ~ p.30
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Effects of Over - dosed Lead and its Interaction with Iron , Copper , Zinc or Protein Supplement in Chicks
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Abstract
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The protective effects of high levels of dietary iron, copper, zinc or protein on lead toxicity were studied In chicks. Growth retardation, reduction of feed intake, anemia and accumulation of lead in the bone and kidney were observed in chicks fed a diet containing 500㎎ lead as chloride per ㎏ of feed for 42 days. Early changes due to ingested lead were inhibition of red blood cell δ-aminolevulinic acid dehydrase at all doses and no effect of iron, copper zinc or protein addition were observed, Tibia lead accumulation was reduced in chicks receiving additional dietary iron or zinc compared to the lead only group but increased in chicks given supplementary protein. Decreased body weight gain was overcome by supplementary zinc or protein in chicks fed lead but not by supplementary iron. Overall the results of this study show that lead poisoning can be partly reduced by providing supplementary iron, zinc or protein, but the interaction of these element remained to be elucidated.
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KEYWORD
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